Effects of GLA

  • γ-linolenic acid is present in oils of human milk and certain seed plants and spore plants, such as Oenothera biennis, which contains 7% to 10% of the product in its seed oil. This product is also found in the oil of borage and vinegar millet. This plant is native to North America and gamma-linolenic acid can be produced in large quantities by microbial fermentation.


    This product is a structural material that constitutes the biofilm of various tissues of the human body, and is also a precursor for the synthesis of prostaglandins. γ-linolenic acid can be produced by the metabolism of linoleic acid in the body, and the daily requirement for adults is about 36 mg/kg. Insufficient intake can lead to disorders in the body and cause certain diseases such as diabetes and hyperlipidemia.

     

    Nutritional health effects of γ-linolenic acid


    1. Anti-cardiovascular effects
      Thromboxane A2 (TXA2) is the most endogenous platelet aggregation agent and vasoconstrictor, while prostacyclin (PGI2) is the most potent vasodilator. The normal body is balanced to maintain the physiological role of the platelets. Once TXA2 synthesis is increased and PGI2 production is reduced, platelet aggregation is increased, causing thrombosis. γ-linolenic acid antithrombotic cardiovascular mechanism: (1) GLAacts as a PGE1 precursor to inhibit platelet aggregation; (2) GLA is converted to DHA, and γ-linolenic acid inhibits platelet TXA2 synthetase activity. Therefore, in the aspect of thrombosis, γ-linolenic acid has a mitigating effect, which can reduce the risk of causing thrombotic cardiovascular and cerebrovascular diseases. It can also inhibit the formation of atherosclerosis, protect the ischemic myocardium, and reduce the necrotic area. To maintain the normal function of platelets.

     

    2, hypolipidemic effect
    γ-linolenic acid as a precursor of PGE1 can reduce total cholesterol. γ-linolenic acid can increase the polarity and water solubility of cholesterol, make it easy to be digested, and can also remove triglyceride from blood, reducing endogenous The synthesis of cholesterol, thereby reducing the production of β-lipoprotein. Therefore, γ-linolenic acid can lower the total cholesterol content in the blood and play a role in lowering blood fat. γ-linolenic acid is currently reported as the most effective and safe drug for the treatment of hyperlipidemia.

     

    3, hypoglycemic effect
    Phospholipids composed of γ-linolenic acid enhance the mobility of phospholipids on cell membranes and enhance the sensitivity of cell membrane receptors to hormones, including insulin. An active substance such as prostaglandin derived from γ-linolenic acid can enhance the function of insulin secretion by islet β-cells. γ-linolenic acid, as a polyunsaturated fatty acid, can also help restore the activity of fatty acid desaturase in diabetic human cells.

     

    4, anti-cancer effect
    Gamma-linolenic acid can be used as a potential anticancer drug. Studies on γ-linolenic acid have shown that it has significant anti-lipid oxidation, because γ-linolenic acid is first oxidized in the body, thereby alleviating cellular lipid peroxidation damage. Studies have shown that γ-linolenic acid can inhibit the growth of human hepatoma cells. Inhibition of human colon cancer, gastric cancer and pancreatic cancer DNA synthesis, γ-linolenic acid plus Fe (II) is effective in the treatment of breast cancer.

     

    5, whitening and anti-aging effect

    The kojic acid monogamma-linolenic acid formed by the reaction of γ-linolenic acid with kojic acid can be used as an inhibitor of tyrosinase, has an anti-melanin-forming effect, and can be used as a functional factor for whitening cosmetics, and can also be used as a cream treatment. Pigmentation. In addition, γ-linolenic acid can be used as a natural oil and fat raw material for cosmetics, and has the functions of protecting skin, moisturizing skin, delaying skin aging, treating chronic eczema, and promoting blood circulation.

     

    Therefore, γ-linolenic acid as a food additive or nutritional supplement, long-term consumption can improve the structure of human food, enhance the body's immune function, so it and other polyunsaturated fatty acids, known as "the protagonist of functional food in the 21st century." Infants, the elderly, adults with metabolic disorders due to obesity, illness or excessive drinking, people with insufficient intake of mineral elements or vitamins should be supplemented with γ-linolenic acid. Some pharmaceutical or food companies have developed gamma-linolenic acid-containing foods for the elderly and children in order to meet the requirements of the above-mentioned specific consumer groups, such as: milk, milk powder, juice, beverages, jellies, biscuits, chocolate, chewing gum, etc.

     

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